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New Delhi: Scientists have discovered inflammatory avenues that contribute to the asthma seizures despite treatment in children.

Eosinophilic asthma is characterized by high levels of eosinophils – a type of white blood cell which is involved in the body’s immune response. Eosinophils usually help fight infections, but in eosinophilic asthma, they accumulate in the lungs and airways, causing chronic inflammation, inflammation and damage to the respiratory system.

Eysinophilic asthma type 2 (T2) is induced by inflammation – an immune response that contains cytokines that promote the production and activation of eosinophils.

Because of this, T2 is used to target inflammation to reduce eosinophil levels and prevent asthma attacks.

“But despite the targeted remedies against T2 inflammation, some children still have asthma attacks. It shows that other inflammatory routes also play a role in asthma attacks,” said Rajesh Kumar, an interim division of allergies and immunology at N&R Luri Children’s Hospital in Chicago, USA.

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In this study published in Jama Pediatrics, scientists used the RNA sequencing method of nasal samples collected during 176 cases of acute respiratory disease.

He identified three different inflammatory causes of asthma attacks.

The first epithelial was an inflammatory passage, which, regardless of viral infection, increased in children receiving the mapolizumab.

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The second was macrophage-powered inflammation, which was particularly associated with viral respiratory diseases, and the third was to the hyperactious and cellular stress reactions of the mucus, which were increased in both treatment and plasibo groups during the flare.

Dr. Kumar said, “We found that the children who worsened the condition even after taking the medicine, had less inflammation of this type of allergy, but there were other residual epithelial routes that were inspiring the inflammatory response that was involved in increasing the situation.”

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Dr. Kumar said that this study throws light on the complexity of asthma in children and emphasizes the need for more personal treatment strategies.

Dr. Kumar said that since asthma in urban communities is impressing children unevenly, information obtained from the study may pave the way for accurate intervention based on the type of inflammation caused by asthma in children, and the quality of life of young patients can improve.