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Vitamin B12: Is it okay to take vitamin B12 on an empty stomach? Learn from an expert about the best time to take the supplement.
KalamTimes | January 26, 2026 7:40 PM CST

Best Way to Take Vitamin B12 Supplement: We're often advised to take vitamin B-12 when we're feeling tired or weak. But the question arises whether it's safe to take on an empty stomach.

Is It Safe To Take Vitamin B12 On An Empty Stomach? Vitamin B12 supplements have become increasingly common these days to address fatigue, nerve health, and vitamin deficiencies. Due to busy lifestyles and the habit of skipping breakfast, many people take them on an empty stomach. But the question remains: is it safe to take vitamin B12 on an empty stomach? Let us answer this question. 

What do experts say?

According to Dr. Priyanka Shekhawat (Neurologist), vitamin B12 is one of those supplements that doesn't have a strict dosage schedule. According to her, it's a water-soluble vitamin that can be taken one hour before or one hour after breakfast. Simply put, it can be taken on an empty stomach or with food, as food doesn't significantly affect its absorption.

 

 

What are the benefits of taking it on an empty stomach?

Experts explain that vitamin B12 is a water-soluble vitamin, meaning it doesn't rely heavily on fat or other nutrients to be absorbed. In some cases, especially with chewable or sublingual tablets, taking them on an empty stomach may result in a slightly faster onset of action. This is because it doesn't compete with other nutrients during digestion.

Who should not take it on an empty stomach?

However, this method may not be comfortable for everyone. According to Dr., some people may experience mild nausea, stomach upset, or discomfort when taking B12 on an empty stomach. Those with acid reflux, gastritis, or sensitive digestive systems may find it safer and more comfortable to take it after a meal.

Does it have any side effects?

Vitamin B12 is generally considered safe. Some people may experience stomach upset, bloating, or a slight metallic taste in the mouth when taken on an empty stomach, but these symptoms are usually mild and resolve quickly. Because it is a water-soluble vitamin, the body excretes excess amounts through urine, reducing the risk of overdose.

Who should be more careful?

According to experts, people with morning sickness during pregnancy, stomach ulcers, or those taking multiple supplements may find it better to take B12 after meals.

If you experience persistent discomfort after taking B12, it's important to consult a doctor.


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