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17 High-Protein Casseroles for Weight Loss
Samira Vishwas | September 3, 2026 12:24 AM CST

Reviewed by Dietitian Jessica Ball, M.S., RD

Credit: Rachel Marek

Whether you’re looking for something simple that feeds the whole family, a dinner that leaves plenty of leftovers or a tasty dish to keep you full for the rest of the night, these flavorful casserole recipes are here to do the job. Nutritious ingredients like lean proteins, legumes and whole grains bring these casseroles at least 15 grams of protein and 6 grams of fiber per serving to help you feel energized and satisfied. Plus, each serving has nor more than 575 calories to support your healthy eating goals while helping you stay nourished. Try our Lasagna with Slow-Roasted Tomato Sauce or Cheesy Black Bean & Quinoa Skillet Casserole for a delicious, cozy meal you’ll want to make again and again.

01 of 17

Beef & Black Bean Nacho Casserole

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Credit: Photographer: Rachel Marek, Food Stylist: Holly Dreesman, Prop Stylist: Sue Mitchell
Credit: Photographer: Rachel Marek, Food Stylist: Holly Dreesman, Prop Stylist: Sue Mitchell

Hominy adds a chewy texture in this healthy casserole, which draws flavor inspiration from nachos. Crushed corn tortilla chips add a crunchy layer to complete the dish. Mild, medium and hot green chiles all work well, so choose what you like best depending on your heat preference.

02 of 17

Lasagna with Slow-Roasted Tomato Sauce

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Slow-roasting the tomatoes gives the tomato sauce for this lasagna recipe an intense depth of flavor—which is then enhanced by the umami in onions, Parmesan and spinach. The lasagna noodles are layered into the lasagna uncooked; the moisture from the fresh spinach cooks them perfectly as the lasagna bakes in the oven.

03 of 17

Chicken Tamale Casserole

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In this Tex-Mex casserole inspired by chicken tamales, a saucy chicken filling with a soft polenta or grits topping is baked in a casserole dish. While it can’t take the place of true tamales, it certainly makes for an easy and scrumptious weeknight dinner.

04 of 17

Shrimp and Cauliflower Bake

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This quick and easy seafood casserole gets bright flavor from fresh dill and feta cheese.

05 of 17

Cheesy Black Bean & Quinoa Skillet Casserole

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Credit: Rachel Marek

This Southwestern-inspired one-skillet casserole is stuffed with quinoa and plenty of fresh vegetables. Sharp Cheddar cheese flavors the filling and adds a layer of ooey-gooey melted cheese on top.

06 of 17

Slow-Cooker Chicken & Pinto Bean Enchilada Casserole

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Credit: Photographer: Greg DuPree, Food Stylist: Ali Ramee Prop Stylist: Christine Keely
Credit: Photographer: Greg DuPree, Food Stylist: Ali Ramee Prop Stylist: Christine Keely

This slow-cooker meal is comfort food at its best: the layers of tortillas, cheese and sauce meld together into a cozy casserole inspired by the flavors in enchiladas. The top tortilla layer gets beautifully crispy in the slow cooker. We use pinto beans, but you could easily swap in black beans.

07 of 17

Anti-Inflammatory Lemony Salmon & Orzo Casserole

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Credit: Stacy k. Allen, Props: Julia Bayless, Food Stylist: Ana Kelley
Credit: Stacy k. Allen, Props: Julia Bayless, Food Stylist: Ana Kelley

This lemony salmon and orzo casserole is a one-dish dinner that’s packed with omega-3 fatty acids—a polyunsaturated fat in salmon that can help tame inflammation and may even help lower blood pressure. Here, omega-3-rich salmon sits on top of an orzo mixture that bakes in the oven, instead of boiling on the stovetop, absorbing all the bright and lemony flavors while it cooks.

08 of 17

Beef & Black Bean Pasta Bake

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This hearty casserole features ground beef, beans, and pasta baked in a flavorful tomato sauce and topped with cheese and sour cream. Kids will love it!

09 of 17

Skillet Green Chile-Chicken Enchilada Casserole

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This 45-minute enchilada recipe is bursting with chicken, tomatoes, tomatillos, chile peppers and cheese, and because it’s a one-skillet casserole, cleanup is a breeze.

10 of 17

Chicken Parmesan Casserole

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Credit: Photographer: Brie Goldman, Food Stylist: Annie Probst, Prop Stylist: Breanna Ghazali
Credit: Photographer: Brie Goldman, Food Stylist: Annie Probst, Prop Stylist: Breanna Ghazali

We took the best parts of chicken Parmesan—melting cheese, crispy breadcrumbs and plenty of tomato sauce—and spun them into an easy family-friendly casserole.

11 of 17

Cheesy Meatball Casserole

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Credit: Jen Causey
Credit: Jen Causey

This cheesy meatball casserole is a family favorite, with basil adding flavor to the meatballs and grated onion adding moisture. Melted mozzarella cheese tames the spice, but feel free to cut back or eliminate the crushed red pepper if you prefer a milder dish.

12 of 17

Two-Bean Enchilada Casserole

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This classic and comforting dish is easy to make on a busy weeknight. Serve this casserole with your favorite toppings, like shredded lettuce, olives or tomatoes.

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Salmon Noodle Casserole

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Credit: Photographer: Brie Goldman, Food Stylist: Charlie Worthington
Credit: Photographer: Brie Goldman, Food Stylist: Charlie Worthington

This salmon noodle casserole is filled with creamy pasta, chunks of salmon and plenty of vegetables for a well-rounded meal. Dijon mustard flavors the dish, complementing the salmon and asparagus.

14 of 17

Nacho Cauliflower Casserole

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Credit: Photographer: Victor Protasio, Food Stylist: Ruth Blackburn, Prop Stylist: Josh Hoggle
Credit: Photographer: Victor Protasio, Food Stylist: Ruth Blackburn, Prop Stylist: Josh Hoggle

This cauliflower casserole is inspired by nachos and stuffed with tender roasted cauliflower, sweet red pepper and brown rice. Salsa helps bind the ingredients together, along with melted cheese. Crushed tortilla chips on top add crunch. Serve with the suggested garnishes, or add your own favorite toppings to complete the dish.

15 of 17

Caprese Casserole

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Credit: Sara Haas
Credit: Sara Haas

This healthy casserole comes together easily, making it the perfect choice for any weeknight dinner. Be sure not to overcook the pasta or it will turn mushy. And don’t skip the balsamic vinegar at the end—it’s a bright finishing touch.

16 of 17

Tuna Casserole with Orzo, Eggplant & Feta

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Tuna casserole is a timeless comfort-food recipe; this one incorporates eggplant, artichoke hearts, oregano, olives and feta cheese for a Greek-inspired flair.

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Chicken, Peppers & Pasta Casserole

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You can assemble this healthy chicken casserole before you leave for a party and pop it in the oven at the host’s house. Or bake it at home and bring it along–it’s delicious at room temperature too.


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