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A desperate search is underway for 84-year-old Nancy Guthrie, the mother of Today show co-anchor Savannah Guthrie. Nancy disappeared from her home on 31 January, with the case being investigated as a possible abduction.

Savannah has since broken her silence on her mum's disappearance, taking to Instagram to thank supporters for their prayers. "We believe in prayer. We believe in voices raised in unison, in love, in hope. We believe in goodness," she wrote in the post's caption. "We believe in humanity. Above all, we believe in Him".

She continued: "Thank you for lifting your prayers with ours for our beloved mom, our dearest Nancy, a woman of deep conviction, a good and faithful servant. raise your prayers with us and believe with us that she will be lifted by them in this very moment."

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Pima County Sheriff Chris Nanos updated reporters on the search for Nancy Guthrie during a press conference on Monday. He declared her home to be a crime scene. "We believe now, after we've processed that crime scene, that we do in fact have a crime scene, that we do in fact have a crime," Nanos said. "And we're asking the community's help."

Nancy was last seen at her home near Tucson, Arizona, on Saturday at around 9.30pm. The 84-year-old was reported missing by her family on Sunday after she did not attend church. Here's everything we know so far...

A number of important personal items were found still inside the home, including Nancy's purse, her keys, and mobile phone, which is being searched by the authorities for clues. Her car was also left behind. Investigators believe this suggests she did not leave voluntarily and was likely abducted.

Nancy requires daily medication - which was also left behind in her home. Savannah's concerned Today co-host Jenna Hager revealed on Monday: "I know her personally. And we want to just report, too, that she takes daily medication and she needs them for survival. She's without her medication. We are thinking of our dearest, dearest Savannah and her whole family right now in our prayers."

"This is an 84-year-old lady who suffers from some physical ailments, has some physical challenges, is in need of medication — medication that, if she doesn't have in 24 hours, it could be fatal," Nanos added in his press conference.

According to the authorities, Nancy has limited mobility, and "did not leave on her own". "She is very limited in her mobility," County Sheriff Chris Nanos said, explaining the grandma "could not walk 50 yards on her own".

Nanos said that while Nancy has trouble walking, she is "of great sound mind". "This is not a dementia-related … She is as sharp as a tack," he said. "The family wants you to know she didn't just wander off," he said. "Her physical limits are based on just age."

While there were no obvious signs of forced entry, Nanos described the scene as "very concerning" and stated that evidence suggests she did not leave on her own. "We believe now, after we've processed that crime scene, that we do, in fact, have a crime," he said.

"We know she didn't just walk out there, that we know. There are other things at the scene that indicate she did not leave on her own, we know that," he added.

NBC News' Tom Winter has further confirmed that the FBI is also involved in the search. He told reporters at a press conference that "concerning evidence" had been found, which prompted homicide investigators to be drafted in.

"This one stood out because of what was described to us at the scene and what we found and located just in looking at the scene," he said. He did not elaborate on what officers had uncovered.